The primary restraint in crop production and food security worldwide is exposure of crop to stress conditions viz., abiotic and biotic which has driven the attention of scientists. Stress conditions induce changes in plant internal functions leads to reduction in plant growth and yield. The adverse economic losses due to abiotic stresses can be mitigated by application of chemicals such as anti-transpirants, nutrients and plant growth regulators, while the biotic stresses by application of pesticides and fungicides. Another way to resist stress conditions is adoption of modern breeding technologies and biotechnological strategies to produce climate resilient crops. Promotion of chemicals and biotechnology tools negatively impacts soil health, environment as well as socio-economic status of the farmer. Though the use of agro-chemicals is unavoidable in modern agriculture, indiscriminate use of chemicals would cause imbalance in environment and reduction in benefit to cost ratio (B: C) of farmer. In this context to make the crop production profitable, the review has outlined different economic considerations associated with biopriming mediation for stress moderation in different crop plants.